Smoked Brisket Grilled Cheese

Are you ready to take your grilled cheese experience to a whole new level? Look no further than this mouthwatering Smoked Brisket Grilled Cheese recipe! Combining the rich flavors of smoked beef brisket with gooey melted cheeses and a touch of barbecue sauce, this sandwich is guaranteed to become your new favorite comfort food.


  • 8 slices thick-cut bread
  • Salted butter, at room temperature
  • ½ tsp Italian seasonings
  • ¼ tsp garlic powder
  • 4 oz. Gruyere cheese, grated
  • 4 oz. sharp cheddar cheese, grated (Cabot’s Seriously Sharp Cheddar recommended)
  • 4 oz. Monterey Jack cheese, grated (Cabot’s Monterey Jack recommended)
  • 12 oz. smoked beef brisket, chopped (~2 cups)
  • 4 tbsp barbecue sauce


  1. Preheat and Prepare: Begin by preheating a large griddle or cast-iron skillet over medium-low heat. While the griddle is heating up, butter one side of each slice of bread. Sprinkle Italian seasonings and garlic powder over the buttered side of the bread slices.
  2. Layering: Place one slice of bread buttered-side down on a clean surface. Layer the grated cheeses, chopped smoked beef brisket, and barbecue sauce on top of the bread slice. Top with another slice of bread, ensuring the buttered side is facing out.
  3. Grill: Carefully place the sandwiches onto the preheated griddle or skillet. Cook over medium-low heat for 3-4 minutes, or until the bottom slice of bread is golden brown.
  4. Flip and Finish: Once the bottom is golden brown, carefully flip the sandwiches and continue cooking until the other side is also golden brown and the cheese has completely melted.
  5. Serve: Remove the sandwiches from the griddle or skillet and serve immediately for the ultimate cheesy, brisket-filled delight.

Nutritional Information:

  • Prep Time: 10 minutes
  • Cooking Time: 10 minutes
  • Total Time: 20 minutes
  • Servings: 4

Serving and Storage Tips:

1. Serving Suggestions:

  • Serve your Smoked Brisket Grilled Cheese alongside a crisp green salad for a balanced meal.
  • Pair it with a bowl of hot tomato soup for the ultimate comfort food experience.
  • Garnish with freshly chopped herbs like parsley or chives for a pop of color and flavor.

2. Cutting Techniques:

  • For easy serving, use a sharp knife to cut the sandwiches diagonally or into quarters.
  • Serve on a platter for a visually appealing presentation, especially when entertaining guests.

3. Storage Instructions:

  • If you have leftovers, allow the sandwiches to cool completely before storing them.
  • Wrap individual sandwiches tightly in aluminum foil or plastic wrap to maintain freshness.
  • Store in an airtight container in the refrigerator for up to 2 days.
  • To reheat, preheat a skillet over medium heat and warm the sandwiches for a few minutes on each side until heated through and crispy.

4. Freezing Option:

  • To freeze, wrap the sandwiches individually in plastic wrap and place them in a freezer-safe bag.
  • Label with the date and store in the freezer for up to 1 month.
  • When ready to enjoy, thaw overnight in the refrigerator and follow the reheating instructions mentioned above.

5. Customization Ideas:

  • Experiment with different types of cheese, such as smoked gouda or pepper jack, to personalize the flavor profile.
  • Add sliced tomatoes or caramelized onions for an extra layer of flavor and texture.
  • Substitute the barbecue sauce with your favorite condiment, like hot sauce or Dijon mustard, for a unique twist.

With these serving and storage tips, you can enjoy the deliciousness of Smoked Brisket Grilled Cheese anytime, anywhere, whether it’s a quick lunch or a satisfying dinner.


1. Pulled Pork Twist:

  • Swap out the smoked beef brisket for tender pulled pork for a Southern-inspired twist on this grilled cheese classic.

2. Veggie Delight:

  • For a vegetarian option, omit the brisket and load up the sandwich with grilled vegetables like bell peppers, onions, and zucchini.

3. Spicy Kick:

  • Kick up the heat by adding sliced jalapeños or a drizzle of sriracha sauce to the sandwich filling for a spicy flavor explosion.

4. Breakfast Edition:

  • Turn this grilled cheese into a hearty breakfast by adding scrambled eggs and crispy bacon to the filling. Perfect for a satisfying start to the day!

5. Mediterranean Fusion:

  • Incorporate Mediterranean flavors by adding roasted red peppers, Kalamata olives, and feta cheese to the sandwich for a tangy and savory twist.

6. BBQ Chicken Variation:

  • Replace the brisket with shredded barbecue chicken and swap out the barbecue sauce for a tangy ranch dressing for a lighter take on the classic.

7. Philly Cheesesteak Style:

  • Channel the flavors of Philadelphia by adding sautéed onions, bell peppers, and thinly sliced steak to the grilled cheese for a Philly Cheesesteak-inspired delight.

8. Hawaiian Influence:

  • Give the sandwich a tropical flair by adding sliced ham, pineapple rings, and a drizzle of teriyaki sauce for a sweet and savory combination.

9. Tex-Mex Twist:

  • Add a Tex-Mex flair with seasoned ground beef, diced tomatoes, sliced avocado, and a dollop of sour cream for a Southwestern-inspired grilled cheese experience.

10. Seafood Sensation:

  • Create a seafood twist by adding crab meat or shrimp along with melted swiss cheese and a sprinkle of Old Bay seasoning for a taste of the coast.

11. Caprese Twist:

  • Add a fresh and light spin to your grilled cheese by layering sliced tomatoes, fresh basil leaves, and creamy mozzarella cheese. Drizzle with balsamic glaze for a burst of flavor.

12. Buffalo Chicken Delight:

  • Transform your grilled cheese into a spicy sensation by combining shredded buffalo chicken, crumbled blue cheese, and thinly sliced celery. Serve with a side of ranch or blue cheese dressing for dipping.

13. Green Goddess Grilled Cheese:

  • Go green with this vibrant variation featuring creamy avocado slices, baby spinach leaves, sliced cucumber, and tangy goat cheese. Perfect for veggie lovers!

14. Mediterranean Mezze:

  • Transport your taste buds to the Mediterranean with a grilled cheese filled with roasted eggplant, sun-dried tomatoes, kalamata olives, and crumbled feta cheese. Drizzle with olive oil and sprinkle with oregano for an extra Mediterranean flair.


Q1: Can I use different types of bread for this recipe?

  • Absolutely! Experiment with your favorite bread varieties like sourdough, ciabatta, or whole wheat for different flavor and texture profiles.

Q2: Can I make this recipe ahead of time for a party?

  • While it’s best enjoyed fresh, you can prepare the components in advance and assemble the sandwiches just before serving to ensure maximum freshness and flavor.

Q3: Can I make this recipe on a regular stovetop instead of a griddle or skillet?

  • Yes, you can! Simply use a non-stick frying pan or skillet over medium-low heat and follow the same cooking instructions.

Q4: Can I substitute the barbecue sauce with another sauce?

  • Of course! Feel free to customize the recipe with your favorite sauce, whether it’s honey mustard, chipotle mayo, or even a homemade aioli.

Q5: Can I make this recipe gluten-free?

  • Yes, you can use gluten-free bread and ensure that all other ingredients, such as barbecue sauce and seasonings, are gluten-free as well.

Q6: How do I know when the sandwiches are done cooking?

  • Look for golden brown, crispy exteriors and melted cheese oozing out from the sides to indicate that the sandwiches are perfectly cooked.

Q7: Can I add additional toppings to the sandwiches?

  • Absolutely! Get creative with your toppings and add-ons to customize the sandwiches to your taste preferences.

Q8: Can I grill these sandwiches outdoors on a barbecue grill?

  • Yes, you can! Simply preheat your grill to medium heat and grill the sandwiches for a few minutes on each side until golden brown and crispy.

Q9: Can I make a larger batch of these sandwiches for a crowd?

  • Certainly! Simply double or triple the ingredients as needed to feed a larger group of people.

Q10: Can I serve these sandwiches as appetizers or party snacks?

  • Definitely! Cut the sandwiches into smaller portions and serve them as bite-sized appetizers for parties or gatherings.

Indulge in the irresistible combination of flavors and textures with this Smoked Brisket Grilled Cheese recipe. Whether it’s for a cozy night in or a gathering with friends, this sandwich is sure to impress!