Cheese Tortellini Pepperoni Pizza Casserole

Are you craving the ultimate comfort food that combines the best of both worlds—pizza and pasta? Look no further than this mouthwatering Cheese Tortellini Pepperoni Pizza Casserole recipe! Packed with cheesy goodness, savory pepperoni, and flavorful sauce, this dish is perfect for satisfying your cravings and impressing your loved ones. Let’s dive into how to create this delightful masterpiece.


  • 16 ounces Cheese Stuffed Tortellini, cooked according to package instructions
  • 2 Garlic Cloves, chopped
  • 1 tablespoon Olive Oil
  • 2 cups Whole Milk
  • ½ teaspoon Dry Italian Seasoning
  • 8 ounces Original Velveeta Cheese, cubed
  • 2 cups Shredded Cheese Blend (mozzarella-based)
  • 2 ounces Pepperoni, quartered
  • ½ cup Pizza Sauce
  • Sliced Pepperoni, for topping
  • 1 cup Shredded Mozzarella Cheese


  1. Preheat Oven: Begin by preheating your oven to 375°F, ensuring it’s nice and hot for baking your casserole to perfection.
  2. Sauté Garlic: In a 3-quart pot over medium heat, add chopped garlic and olive oil. Sauté the garlic, stirring constantly, until it turns golden and releases its aromatic flavors, usually about 1 minute.
  3. Prepare Creamy Sauce: Pour in the whole milk and sprinkle in the dry Italian seasoning. Stir the mixture until the milk starts to steam gently.
  4. Add Cheeses: Lower the heat and add in the cubed Velveeta cheese and shredded cheese blend. Continuously stir until the cheeses melt completely, creating a smooth and creamy sauce that will be the star of your casserole.
  5. Incorporate Tortellini and Pepperoni: Once the cheese sauce is silky smooth, turn off the heat but leave the pot on the burner. Add the cooked tortellini and quartered pepperoni to the cheese sauce, stirring gently to coat every delicious bite.
  6. Transfer to Casserole Dish: Carefully transfer the cheesy tortellini mixture into a casserole dish, ensuring it’s evenly spread out for even baking.
  7. Layer Pizza Sauce: Dollop the pizza sauce on top of the cheesy tortellini mixture, then gently swirl it in without fully mixing to create a beautiful marbled effect.
  8. Top with Pepperoni and Cheese: Arrange slices of pepperoni on top of the sauce layer, adding an extra kick of flavor and visual appeal. Sprinkle shredded mozzarella cheese generously over the pepperoni, ensuring every bite is packed with cheesy goodness.
  9. Bake to Perfection: Place the casserole dish on the center rack of your preheated oven and bake uncovered for 25 minutes. For that irresistible golden brown finish, broil on high for an additional 3-4 minutes, keeping a close eye to prevent burning.
  10. Serve and Enjoy: Once the cheese is bubbling and the aroma fills your kitchen, it’s time to take out your masterpiece. Serve hot and enjoy the cheesy, pepperoni-packed goodness with your family and friends!


Serving Tips:

  1. Garnish Creatively: Sprinkle some freshly chopped parsley or basil on top before serving to add a pop of color and freshness.
  2. Pair with Salad: Balance the richness of the casserole with a crisp green salad dressed in a light vinaigrette for a well-rounded meal.
  3. Serve with Garlic Bread: Accompany the casserole with some warm, garlic-infused breadsticks or crusty garlic bread for a complete Italian-inspired feast.
  4. Individual Portions: Consider portioning the casserole into individual serving dishes for a stylish presentation at dinner parties or gatherings.
  5. Customize Toppings: Encourage your guests to customize their servings by offering additional toppings like olives, mushrooms, or diced bell peppers.

Storage Tips:

  1. Refrigeration: Store any leftovers in an airtight container in the refrigerator for up to 3-4 days.
  2. Freezing: This casserole can also be frozen for longer storage. Transfer cooled leftovers into freezer-safe containers or zip-top bags, removing as much air as possible. Label with the date and store in the freezer for up to 2-3 months.
  3. Reheating: To reheat, simply thaw frozen portions overnight in the refrigerator if necessary, then microwave individual servings or reheat in the oven at 350°F until heated through. You can also reheat larger portions in a covered casserole dish at 325°F until warmed to your liking.
  4. Revive Crispiness: If the cheese topping loses its crispiness upon reheating, try placing the casserole under the broiler for a few minutes to re-crisp the cheese.
  5. Enjoy Responsibly: Remember to discard any leftovers that have been left at room temperature for more than 2 hours to ensure food safety.

By following these serving and storage tips, you can make the most out of your Cheese Tortellini Pepperoni Pizza Casserole, ensuring delicious enjoyment from the first bite to the last. Whether you’re savoring it fresh from the oven or reheating leftovers for a quick and satisfying meal, this casserole is sure to delight your taste buds every time!



  1. Vegetarian Twist: For a vegetarian option, omit the pepperoni and add a variety of roasted vegetables such as bell peppers, zucchini, and mushrooms to the cheesy tortellini mixture. You can also use a vegetable-based pizza sauce for added flavor.
  2. Meat Lover’s Delight: Double up on the meaty goodness by adding cooked Italian sausage or crumbled bacon along with the pepperoni. Customize the meat selection to suit your preferences for a heartier dish.
  3. Spicy Kick: For those who love a bit of heat, sprinkle crushed red pepper flakes into the cheese sauce or use spicy pepperoni for an extra kick of flavor. You can also add diced jalapeños or banana peppers for additional heat and tanginess.
  4. Four Cheese Blend: Experiment with different types of cheeses to create a more complex flavor profile. Try incorporating shredded cheddar, fontina, or provolone cheese along with the mozzarella and Velveeta for a decadent four-cheese blend.
  5. Pesto Twist: Replace the pizza sauce with creamy pesto sauce for a flavorful twist on traditional pizza flavors. Garnish with fresh basil leaves before serving to enhance the herbaceous notes.
  6. Mushroom and Spinach Variation: Sauté sliced mushrooms and fresh spinach in garlic and olive oil until tender, then mix them into the cheesy tortellini mixture before baking. This adds earthy flavors and an extra dose of nutrients to the dish.
  7. Buffalo Chicken Style: Toss cooked diced chicken in buffalo sauce before adding it to the cheesy tortellini mixture. Drizzle extra buffalo sauce over the top before baking for a spicy and tangy flavor profile reminiscent of buffalo chicken pizza.
  8. Tex-Mex Fusion: Incorporate Mexican-inspired ingredients by adding black beans, corn, and diced green chilies to the cheesy tortellini mixture. Top with salsa and sliced avocado before serving for a Tex-Mex twist on pizza casserole.

Feel free to get creative and customize this Cheese Tortellini Pepperoni Pizza Casserole to suit your taste preferences and dietary needs. With these variations, you can enjoy a delicious and satisfying meal that’s tailored to your liking every time!

FAQs (Frequently Asked Questions):

  1. Can I use frozen tortellini instead of fresh? Yes, frozen tortellini can be substituted for fresh tortellini in this recipe. Simply follow the cooking instructions on the package before incorporating them into the casserole.
  2. Can I make this casserole ahead of time? Absolutely! You can assemble the casserole up to a day in advance, cover it tightly with foil, and refrigerate until ready to bake. Allow the casserole to come to room temperature before baking as directed in the recipe.
  3. Can I use different types of cheese in the sauce? Yes, feel free to experiment with different cheeses to suit your taste preferences. While the recipe calls for Velveeta and mozzarella-based cheese blend, you can substitute with your favorite cheeses such as cheddar, provolone, or gouda.
  4. Is this recipe suitable for vegetarians? This recipe can easily be adapted for vegetarians by omitting the pepperoni and using vegetable-based broth in place of chicken broth. You can also add additional vegetables like spinach, mushrooms, or bell peppers for a hearty vegetarian option.
  5. Can I freeze leftovers? Yes, this casserole freezes well. Once cooled, portion out any leftovers into freezer-safe containers or zip-top bags, removing as much air as possible before freezing. Thaw overnight in the refrigerator before reheating.  

with its perfect blend of cheesy tortellini, savory pepperoni, and luscious sauce, this Cheese Tortellini Pepperoni Pizza Casserole is a guaranteed crowd-pleaser. Whether you’re hosting a family dinner or attending a potluck, this indulgent dish will surely steal the show. So, roll up your sleeves, gather your ingredients, and get ready to dive into comfort food heaven!